BDBM50182833 CHEMBL382362::N-(5-(3-(1-acetylpiperazine-4-carbonyl)-4,5-dimethylbenzylthio)thiazol-2-yl)-4-((3,3-dimethylbutan-2-ylamino)methyl)benzamide

SMILES CC(NCc1ccc(cc1)C(=O)Nc1ncc(SCc2cc(C)c(C)c(c2)C(=O)N2CCN(CC2)C(C)=O)s1)C(C)(C)C

InChI Key InChIKey=DQPJVNQWPBLBAB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50182833   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182833(CHEMBL382362 | N-(5-(3-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  96nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182833(CHEMBL382362 | N-(5-(3-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  650nMAssay Description:Inhibition of anti-CD3 antibody-induced IL2 production in human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182833(CHEMBL382362 | N-(5-(3-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  700nMAssay Description:Inhibition of anti-CD3 antibody-induced IL2 production in human jurkat T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182833(CHEMBL382362 | N-(5-(3-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed