BDBM50183786 (2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyphenyl)-4-oxo-4-(piperidin-1-yl)butanamide::CHEMBL206875

SMILES COc1ccc(cc1)[C@H]([C@H](CO)C(=O)NO)C(=O)N1CCCCC1

InChI Key InChIKey=ZFXFRRPQPVEFAM-LSDHHAIUSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183786   

TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  55nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  66nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  213nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  300nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed