BDBM50187717 CHEMBL3828269

SMILES Cn1cc(cn1)-c1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1

InChI Key InChIKey=MSSFKFFUKSRZMQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187717   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187717(CHEMBL3828269)
Affinity DataIC50:  3nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187717(CHEMBL3828269)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187717(CHEMBL3828269)
Affinity DataIC50:  801nMAssay Description:Inhibition of cytoplasmic GST-tagged human ErbB4 expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187717(CHEMBL3828269)
Affinity DataIC50:  676nMAssay Description:Inhibition of cytoplasmic His-tagged human ErbB2 expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187717(CHEMBL3828269)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R/T790M double mutant (668-1210 residues) expressed in baculovirus system by z-lyte a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed