BDBM50187959 CHEMBL211870::rac-6-bromo-9a-ethyl-1-fluoro-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

SMILES CCC12Cc3c(ccc4[nH]nc(F)c34)C1=C(Br)C(=O)CC2

InChI Key InChIKey=SCHWUMPHNXKRIU-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50187959   

TargetEstrogen receptor beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187959(CHEMBL211870 | rac-6-bromo-9a-ethyl-1-fluoro-8,9,9...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human ERbeta transfected in HEK293 cells assessed as transactivation of alkaline phosphatase reporter geneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187959(CHEMBL211870 | rac-6-bromo-9a-ethyl-1-fluoro-8,9,9...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity to human ERbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187959(CHEMBL211870 | rac-6-bromo-9a-ethyl-1-fluoro-8,9,9...)
Affinity DataEC50:  33.1nMAssay Description:Agonist activity at human ERalpha transfected in HEK293 cells assessed as transactivation of alkaline phosphatase reporter geneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187959(CHEMBL211870 | rac-6-bromo-9a-ethyl-1-fluoro-8,9,9...)
Affinity DataIC50:  197nMAssay Description:Binding affinity to human ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed