BDBM50188623 CHEMBL380274::N-tert-butyl-N'-[2-(4-methylphenylthio)-5-nitrobenzenesulfonyl]urea

SMILES Cc1ccc(Sc2ccc(cc2S(=O)(=O)NC(=O)NC(C)(C)C)[N+]([O-])=O)cc1

InChI Key InChIKey=AJBWMHGSVUAWPG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50188623   

TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of LièGe

Curated by ChEMBL
LigandPNGBDBM50188623(CHEMBL380274 | N-tert-butyl-N'-[2-(4-methylphenylt...)
Affinity DataIC50:  1.74nMAssay Description:Displacement of [3H]SQ29,548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of LièGe

Curated by ChEMBL
LigandPNGBDBM50188623(CHEMBL380274 | N-tert-butyl-N'-[2-(4-methylphenylt...)
Affinity DataIC50:  55.2nMAssay Description:Activity at TPbeta (long isoform) receptor expressed in HEK293 cells assessed as ability to antagonize U46619-mediated calcium ion mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of LièGe

Curated by ChEMBL
LigandPNGBDBM50188623(CHEMBL380274 | N-tert-butyl-N'-[2-(4-methylphenylt...)
Affinity DataIC50:  294nMAssay Description:Activity at TPalpha (short isoform) receptor expressed in HEK293 cells assessed as ability to antagonize U46619-mediated calcium ion mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of LièGe

Curated by ChEMBL
LigandPNGBDBM50188623(CHEMBL380274 | N-tert-butyl-N'-[2-(4-methylphenylt...)
Affinity DataIC50:  0.770nMAssay Description:Displacement of [3H]SQ29,548 from TPalpha receptor (short isoform) expressed in COS7 cells at 1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of LièGe

Curated by ChEMBL
LigandPNGBDBM50188623(CHEMBL380274 | N-tert-butyl-N'-[2-(4-methylphenylt...)
Affinity DataIC50:  800nMAssay Description:Inhibition of U46619-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed