BDBM50188913 CHEMBL213618::N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide::N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE

SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl

InChI Key InChIKey=HHOVRZGUSBMKKU-ZDUSSCGKSA-N

Data  13 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50188913   

TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataEC50:  160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataEC50:  370nMAssay Description:Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Affinity DataEC50:  320nMAssay Description:Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed