BDBM50189278 6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemicarbazone 1,1-dioxide::CHEMBL214219

SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(Br)cc12

InChI Key InChIKey=XOBXSIZLGQEDSF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50189278   

TargetCruzipain(Trypanosoma cruzi)
Baylor University

Curated by ChEMBL
LigandPNGBDBM50189278(6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemic...)
Affinity DataIC50:  210nMAssay Description:Inhibition of Trypanosoma cruzi recombinant cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50189278(6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemic...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50189278(6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemic...)
Affinity DataIC50:  574nMAssay Description:Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed