BDBM50189704 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-5-isobutyryl-2-[4-(3-methyluriedo)phenyl]-4-oxothieno[2,3-b]pyridine::CHEMBL377396

SMILES CNC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)cc(C(=O)C(C)C)c(=O)c2c1CN(C)Cc1ccccc1

InChI Key InChIKey=YEVRFOQFAUPFAJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50189704   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189704(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189704(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189704(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189704(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50:  200nMAssay Description:Inhibition of [125I]leuprorelin binding to rat anterior pituitary LHRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed