BDBM50191818 (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopropyl-4-[(1R,3R')-3'methyl-1'H-spiro[indene-1,4'-piperidin]-1'yl]butanamide::CHEMBL441856

SMILES C[C@H]1CN(CC[C@@H](C2CC2)C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)CC[C@@]11C=Cc2ccccc12

InChI Key InChIKey=XLRKVUXIKLTNKO-TVIOGVOPSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50191818   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50:  4nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed