BDBM50192399 4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL213593

SMILES Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl

InChI Key InChIKey=YSCJJRUJHLWETL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192399   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192399(4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carb...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition at human Chk1 in presence of 4 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192399(4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carb...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Chulalongkorn University

Curated by ChEMBL
LigandPNGBDBM50192399(4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carb...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Chulalongkorn University

Curated by ChEMBL
LigandPNGBDBM50192399(4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carb...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Chulalongkorn University

Curated by ChEMBL
LigandPNGBDBM50192399(4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carb...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human Wee1 in presence of 9.5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed