BDBM50197220 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5-dichloroisonicotinoyl)-N-hydroxypiperidine-4-carboxamide::CHEMBL391881

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)C(=O)c1c(Cl)cncc1Cl)C(=O)NO

InChI Key InChIKey=IDHBZDJZPPEMGC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50197220   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50197220(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50197220(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5...)
Affinity DataIC50:  183nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50197220(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5...)
Affinity DataIC50:  449nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50197220(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of TACE in human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed