BDBM50197400 2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL240622

SMILES COc1cc(F)ccc1OC(C)(C)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O

InChI Key InChIKey=OXJFVFXQQOZVHD-TXBRZDKCSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50197400   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197400(2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfony...)
Affinity DataKi:  7nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197400(2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfony...)
Affinity DataKi:  20nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197400(2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfony...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human HSD1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197400(2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfony...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human HSD2 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197400(2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfony...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse HSD2 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed