BDBM50198031 CHEMBL227598::[(R)-1-(4'-isopropoxy-biphenyl-4-sulfonylamino)-2-methyl-propyl]-phosphonic acid

SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O

InChI Key InChIKey=VKFNDAOTTJONML-LJQANCHMSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50198031   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  130nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant MMP9 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  36nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50198031(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)
Affinity DataIC50:  600nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed