BDBM50205268 ARRY-334543::ARRY-543::ASLAN-001::Varlitinib

SMILES C[C@@H]1COC(Nc2ccc3ncnc(Nc4ccc(OCc5nccs5)c(Cl)c4)c3c2)=N1

InChI Key InChIKey=UWXSAYUXVSFDBQ-CYBMUJFWSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50205268   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  2nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  4nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant His-tagged HER2 (catalytic domain 691 to 1255 residues) using polyglutamic acid/tyrosine as substrate by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant full length EGFR using polyglutamic acid/tyrosine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed