BDBM50212297 (1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4,20-diazapentacyclo[8.7.3.0^{1,9}.0^{3,7}.0^{12,17}]icosa-3(7),4,12(17),13,15-pentaen-15-ol::CHEMBL376355

SMILES Nc1nc2C[C@]34CCN(CC5CCC5)[C@H](Cc5ccc(O)cc35)[C@@H]4Cc2s1

InChI Key InChIKey=LLZGBQVJBUASJT-LRXVAGHRSA-N

Data  3 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50212297   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataIC50:  93nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO membrane assessed as inhibition of U50488-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO membrane assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO membrane assessed as inhibition of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed