BDBM50227829 CHEBI:8455::CHLOROGUANIDE::Proguanil

SMILES CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1

InChI Key InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N

Data  1 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50227829   

TargetTrace amine-associated receptor 1(Homo sapiens (Human))
University Of Genoa

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | CHLOROGUANIDE | Proguanil)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | CHLOROGUANIDE | Proguanil)
Affinity DataIC50:  1.18E+5nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells membrane vesicles assessed inhibition of BCRP- mediated transport of 3[H]-E1S fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Genoa

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | CHLOROGUANIDE | Proguanil)
Affinity DataEC50:  5.40E+3nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 5(Mus musculus)
University Of Genoa

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | CHLOROGUANIDE | Proguanil)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed