BDBM50228409 8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione::CHEMBL399216

SMILES Cn1c2nc(N3CCCC(N)C3)n(Cc3ccccc3)c2c(=O)n(C)c1=O

InChI Key InChIKey=BLGQZJNVPWQDPL-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50228409   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50228409(8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50228409(8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50228409(8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human recombinant DPP4 (39 to 766 residues) using Ala-Pro-AFC as substrate incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50228409(8-(3-aminopiperidin-1-yl)-7-benzyl-1,3-dimethyl-1H...)
Affinity DataKd:  13nMAssay Description:Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed