BDBM50230926 CHEMBL4083504

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(NC(=O)CN3CCOCC3)c(OC)c2c1

InChI Key InChIKey=PESHAFCSMREEAN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50230926   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50230926(CHEMBL4083504)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged mTOR (1362-end residues) using ULight-4E-BP1 peptide substrate after 1 hr in presence of ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50230926(CHEMBL4083504)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3K p110alpha/p85alpha (unknown origin) using PIP2 as substrate after 1 hr by luminescent kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50230926(CHEMBL4083504)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of PI3K p110delta (unknown origin) using PIP2 as substrate after 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50230926(CHEMBL4083504)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of recombinant full length His-tagged human PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate after 1 hr b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50230926(CHEMBL4083504)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant full length human N-terminal His6-tagged PI3K p110beta/p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed