BDBM50234144 1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)urea::CHEMBL253292

SMILES CCN(CC)CCOc1ccc(Nc2cc(NC(=O)Nc3c(Cl)cccc3Cl)ncn2)cc1

InChI Key InChIKey=FOMAIMPXVLHOCI-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50234144   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  570nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Axl kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  570nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  66nMAssay Description:Inhibition of cSrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  380nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  250nMAssay Description:Inhibition of cABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  930nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  960nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50:  430nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50234144(1-(2,6-dichlorophenyl)-3-(6-(4-(2-(diethylamino)et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed