BDBM50235036 CHEMBL4082309

SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12

InChI Key InChIKey=ZYDSDRZMIWGATN-HOTGVXAUSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50235036   

TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50:  124nMAssay Description:Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataEC50:  2.35E+4nMAssay Description:Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as MDM2-pre mRNA exon skipping after 4 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human CLK3 using ERMRPRKRQGSVRRRV as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50:  56nMAssay Description:Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human CDK4/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human CDK6/cyclinD3 using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50:  14nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50235036(CHEMBL4082309)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human CDK1/cyclinB using Histone H1 as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed