BDBM50240928 CHEMBL4067280

SMILES Cn1c2nc(S)n(CC(O)COc3ccc(Cl)cc3)c2c(=O)[nH]c1=O

InChI Key InChIKey=NZAKNENBMNKYOA-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50240928   

TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50240928(CHEMBL4067280)
Affinity DataKi:  105nMAssay Description:Competitive inhibition of AEP (unknown origin) using varying levels of Z-AAN-AMC substrate after 10 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50240928(CHEMBL4067280)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of cathepsin-S (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50240928(CHEMBL4067280)
Affinity DataIC50:  2.97E+4nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50240928(CHEMBL4067280)
Affinity DataIC50:  370nMAssay Description:Inhibition of AEP (unknown origin) using Cbz-Ala-Ala-Asn-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50240928(CHEMBL4067280)
Affinity DataIC50:  7.61E+4nMAssay Description:Inhibition of caspase-8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed