BDBM50241832 CHEMBL4083986::US10626113, Compound C::US10899756, Compound C

SMILES CCN1CCc2nc3ccc(cc3c(NCc3ccc(OC)c(Cl)c3)c2C1)C#N

InChI Key InChIKey=BHHKINOUCSOPMW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50241832   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241832(CHEMBL4083986 | US10626113, Compound C | US1089975...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241832(CHEMBL4083986 | US10626113, Compound C | US1089975...)
Affinity DataIC50:  0.200nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50241832(CHEMBL4083986 | US10626113, Compound C | US1089975...)
Affinity DataIC50:  0.200nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In DepthDetails US Patent