BDBM50242139 CHEMBL4078721

SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(CNC(=O)C[C@H](OC1=O)\C=C\CCSCCS)n2

InChI Key InChIKey=WEFWTSUXXXOIID-RQRZMCCBSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50242139   

TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  43nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  90nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substrate 3 after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 insect cells using BPS HDAC class 2a substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC10 (1 to 481 residues) expressed in baculovirus infected Sf9 insect cells using B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using HDAC substrate 3 after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed