BDBM50242157 CHEMBL4070894::US10626113, Compound B::US10899756, Compound B

SMILES COc1ccc(CNc2c3CN(C)CCc3nc3ccc(cc23)C#N)cc1Cl

InChI Key InChIKey=SZSQUMVPZIONEO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50242157   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242157(CHEMBL4070894 | US10626113, Compound B | US1089975...)
Affinity DataIC50:  0.590nMAssay Description:Concentration required to inhibit the activity of K+ stimulated gastric ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242157(CHEMBL4070894 | US10626113, Compound B | US1089975...)
Affinity DataIC50:  1nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50242157(CHEMBL4070894 | US10626113, Compound B | US1089975...)
Affinity DataIC50:  1nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In DepthDetails US Patent