BDBM50244767 4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid::4-[[4-Oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid::CHEMBL461939

SMILES OC(=O)c1ccc(\C=C2/SC(=S)N(C2=O)c2cccc(c2)C(F)(F)F)cc1

InChI Key InChIKey=JIMHYXZZCWVCMI-ZSOIEALJSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244767   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human wild type CFTR expressed in rat FRT cells assessed as chloride current by short-circuit current measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  6.39E+3nMAssay Description:Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophage cells assessed as effect on IL-1beta produc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  300nMAssay Description:Inhibition of CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50244767(4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)th...)
Affinity DataIC50:  300nMAssay Description:Inhibition of CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed