BDBM50245225 CHEMBL4099097::US11116757, No. A15

SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=KMESDCFVSCNOKG-UHFFFAOYSA-N

Data  5 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50245225   

TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataIC50:  50nMAssay Description:Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-conjugating enzyme Ubc12(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to N-terminally acetylated human UBE2MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataEC50:  79nMAssay Description:Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataIC50:  53nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataKd:  140nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataIC50:  88.5nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataIC50:  53nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50245225(CHEMBL4099097 | US11116757, No. A15)
Affinity DataIC50:  62nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed