BDBM50245225 CHEMBL4099097::US11116757, No. A15
SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
InChI Key InChIKey=KMESDCFVSCNOKG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50245225
Affinity DataIC50: 50nMAssay Description:Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
TargetNEDD8-conjugating enzyme Ubc12(Homo sapiens)
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to N-terminally acetylated human UBE2MMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acet...More data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center
US Patent
Memorial Sloan Kettering Cancer Center
US Patent
Affinity DataIC50: 53nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 by ITC methodMore data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center
US Patent
Memorial Sloan Kettering Cancer Center
US Patent
Affinity DataIC50: 88.5nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center
US Patent
Memorial Sloan Kettering Cancer Center
US Patent
Affinity DataIC50: 53nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair