BDBM50245386 3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1H)-yl)-N-(methylsulfonyl)propanamide::CHEMBL460940::N-[3-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1H )-yl)-propanoyl]methanesulfonamide
SMILES CS(=O)(=O)NC(=O)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl
InChI Key InChIKey=DOAXPKHKQSQJOY-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50245386
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
Affinity DataIC50: >3.40E+3nMAssay Description:Inhibition of Cdc2/cyclin B assessed as inhibition of histone H1 phosphorylation in human HT29 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of Cdc2 Tyr15 phosphorylation in human HT29 cells by western blotMore data for this Ligand-Target Pair