BDBM50245420 CHEMBL462168::N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)-3-(trifluoromethyl)benzamide

SMILES COc1cc2nccc(Oc3ccc4c(NC(=O)c5cccc(c5)C(F)(F)F)nn(C)c4c3)c2cc1OC

InChI Key InChIKey=VCBGNDQGKNIBBK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50245420   

TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  45nMAssay Description:Inhibition of aurora 1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  121nMAssay Description:Inhibition of Tie 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  764nMAssay Description:Inhibition of aurora 2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  2.50E+7nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  3.25E+3nMAssay Description:Inhibition of PI3KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  3.32E+3nMAssay Description:Inhibition of cMETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  2.50E+7nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed