BDBM50245458 4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1H)-yl)butanoic acid::CHEMBL511992

SMILES OC(=O)CCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1Cl

InChI Key InChIKey=ATWQVWMVBKTFSI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50245458   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245458(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50: >3.40E+3nMAssay Description:Inhibition of Cdc2/cyclin B assessed as inhibition of histone H1 phosphorylation in human HT29 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245458(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245458(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cdc2 Tyr15 phosphorylation in human HT29 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245458(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed