BDBM50245525 3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1H)-yl)propanenitrile::CHEMBL511280
SMILES Oc1ccc2n(CCC#N)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl
InChI Key InChIKey=WQQQJDAMPWMJLM-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50245525
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
Affinity DataIC50: >3.40E+3nMAssay Description:Inhibition of Cdc2/cyclin B assessed as inhibition of histone H1 phosphorylation in human HT29 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: <250nMAssay Description:Inhibition of Cdc2 Tyr15 phosphorylation in human HT29 cells by Western blotMore data for this Ligand-Target Pair