BDBM50246649 (R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)ureido)acetate::CHEMBL508974
SMILES CCOC(=O)CNC(=O)NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1
InChI Key InChIKey=DLLWIQHESQBDLY-AREMUKBSSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50246649
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.151nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye ba...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.126nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.0631nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.427nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye base...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.708nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye bas...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)
Curated by ChEMBL
Affinity DataIC50: 0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair