BDBM50253611 2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylamino]quinazoline::CHEMBL522543

SMILES CCN(Cc1cc(Cl)cc(Cl)c1Cl)c1ccc2nc(N)nc(N)c2c1

InChI Key InChIKey=LAQLUYMJSYVNIA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50253611   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50253611(2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50253611(2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Mycobacterium avium dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50253611(2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)
Affinity DataIC50:  19nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50253611(2,4-Diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylam...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed