BDBM50253780 CHEMBL517875::Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)acetate

SMILES CCOC(=O)CN(Cc1ccccc1)c1ccc2N(C)CC(C)(COc3ccc(cc3)C(N)=N)Oc2c1

InChI Key InChIKey=RYOHTLPDVCSHSF-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50253780   

TargetProthrombin(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataKi:  320nMAssay Description:Inhibition of thrombin using S-2238 as substrate preincubated for 15 mins prior substrate addition measured for every 10 secs by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataKi:  380nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataKi:  2.67E+3nMAssay Description:Inhibition of factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of factor 10a using S-2222 as substrate preincubated for 15 mins prior substrate addition measured for every 10 secs by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of biotinylated fibrinogen from human alpha5-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of fibrinogen binding to human platelet GPIIb/IIIa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50253780(CHEMBL517875 | Ethyl 2-(benzyl{2-[(4-carbamimidoyl...)
Affinity DataIC50:  2.80E+4nMAssay Description:Displacement of biotinylated fibrinogen from human alpha2b-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed