BDBM50254388 CHEMBL4101680
SMILES FC(F)(F)Oc1ccc2c(n[nH]c2c1)-c1ccc(cc1)C#N
InChI Key InChIKey=RIUFXWHYQAUEAO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50254388
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of Nav1.7 (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2(Homo sapiens)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to SK2 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 686nMAssay Description:Inhibition of full length human TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of KCNQ1 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 246nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 195nMAssay Description:Inhibition of full length human TRPA1 oS5 chimera at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair