BDBM50254401 CHEMBL4093377

SMILES FC(F)(F)c1ccc2c(Nc3ccc(Cl)nc3)n[nH]c2c1

InChI Key InChIKey=GNYBHKXPQGYGCV-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50254401   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataIC50:  8.52E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to SK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of KCNQ1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataIC50:  550nMAssay Description:Antagonist activity at human TRPA1 by calcium flux based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataIC50: >1.00E+5nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity at human TRPA1 by calcium flux based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed