BDBM50257656 CHEMBL493107::N-(5-((cyclohexylamino)methyl)-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(2-methyloxazol-5-yl)thiophene-2-carboxamide

SMILES Cc1ncc(o1)-c1ccc(s1)C(=O)Nc1nc2cc(CNC3CCCCC3)ccc2n1CC(C)(C)O

InChI Key InChIKey=NMTCBMKWFHUPEP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257656   

TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257656(CHEMBL493107 | N-(5-((cyclohexylamino)methyl)-1-(2...)
Affinity DataIC50:  700nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257656(CHEMBL493107 | N-(5-((cyclohexylamino)methyl)-1-(2...)
Affinity DataIC50:  940nMAssay Description:Inhibition of ITK (unknown origin) in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257656(CHEMBL493107 | N-(5-((cyclohexylamino)methyl)-1-(2...)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257656(CHEMBL493107 | N-(5-((cyclohexylamino)methyl)-1-(2...)
Affinity DataIC50:  8nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed