BDBM50262764 2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfanyl)-7Hpyrrolo[2,3-d]pyrimidine::CHEMBL478404

SMILES COc1ccc(Sc2[nH]c3nc(N)nc(N)c3c2C(C)C)cc1

InChI Key InChIKey=MZSSVCUBSWSWFB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50262764   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262764(2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfany...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262764(2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfany...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262764(2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfany...)
Affinity DataIC50:  600nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262764(2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfany...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262764(2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfany...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262764(2,4-Diamino-5-isopropyl-6-(4'-methoxyphenylsulfany...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed