BDBM50265966 CHEMBL4103768
SMILES Cn1c2CCN(Cc3ccccc3)C(=O)c2cc1-c1ccnc(NC2CCOCC2)n1
InChI Key InChIKey=UQFPBBSPMHMAFE-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50265966
Affinity DataIC50: <0.480nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATPMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATPMore data for this Ligand-Target Pair