BDBM50268441 1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3-phenylpropan-1-one::CHEMBL447085

SMILES Fc1ccc2OC3(CCN(CC3)C(=O)CCc3ccccc3)CCc2c1

InChI Key InChIKey=DZCNPAGZPPBTBP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50268441   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of Voltage-gated sodium channel subunit alpha Nav1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human microsomal epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268441(1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed