BDBM50268442 (+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)spiro[chroman-2,4'-piperidine]-1'-carboxamide::CHEMBL495601

SMILES O=C(NC1CCc2ccccc2C1)N1CCC2(CC1)CC(=O)c1ccccc1O2

InChI Key InChIKey=RSJUYPGFGAQOLP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50268442   

TargetEpoxide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human microsomal epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50:  39nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Voltage-gated sodium channel subunit alpha Nav1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268442((+/-)-4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)s...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed