BDBM50272272 CHEMBL502528::N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)pentyl]benzoyl}-L-glutamic Acid

SMILES Nc1nc2[nH]c(CCCCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1

InChI Key InChIKey=VGLCUJLZYVTUKW-KRWDZBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50272272   

TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wayne State University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50272272(CHEMBL502528 | N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Wayne State University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50272272(CHEMBL502528 | N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-...)
Affinity DataIC50:  2.26E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed