BDBM50274385 4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile::CHEMBL489058
SMILES CCN1CCN(CC\C=C\c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(cnc3c2)C#N)CC1
InChI Key InChIKey=OYAMULIHRWEUAR-GQCTYLIASA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50274385
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of PKCtheta (unknown origin) in presence of 6 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of Tpl2 (unknown origin) in presence of 50 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MK2 (unknown origin) in presence of 1 uM ATPMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 225nMAssay Description:Inhibition of MEK1-mediated ERK phosphorylation in human WM266-4 cells after 2.5 hrsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of Src (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of Lyn (unknown origin) in presence of 20 uM ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of 1 uM ATPMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of B-raf (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 9.17E+3nMAssay Description:Inhibition of IKKbeta (unknown origin) in presence of 2 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of P70S6 (unknown origin) in presence of 2 uM ATPMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of AKT (unknown origin) in presence of 20 uM ATPMore data for this Ligand-Target Pair