BDBM50274640 CHEMBL4126445

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C

InChI Key InChIKey=CNCRCDLWUGCPSJ-LBPRGKRZSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50274640   

LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mus musculus (Mouse))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 15 mins followed by C5a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  87nMAssay Description:Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins by alphalisa assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  126nMAssay Description:Inhibition of recombinant human full length GST-tagged CLK4 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110alpha/human p85alpha co- expressed in Sf9 insect cells using phosphatidyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110beta/human p85alpha co- expressed in Sf9 insect cells using phosphatidyli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full-length human PI3K p110delta/p85alpha co- expressed in Sf9 insect cells using phosphatidylinosito...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human full length GST-tagged DRAK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed