BDBM50290835 (3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine::CHEMBL100714::CHEMBL544833
SMILES COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1OC
InChI Key InChIKey=CCHZXKUIBPNVKD-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50290835
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up ...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 7.38E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair