BDBM50290836 (3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-amine::CHEMBL98248

SMILES COc1cc2nccc(Nc3cccc(Br)c3)c2cc1OC

InChI Key InChIKey=WCVTXEYTMLUPPQ-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50290836   

TargetPlatelet-derived growth factor receptor beta(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Affinity DataIC50:  2.15E+4nMAssay Description:Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Affinity DataIC50:  370nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Affinity DataKd:  240nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Affinity DataIC50:  170nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Affinity DataIC50:  510nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290836((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Affinity DataKd:  58nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed