BDBM50294270 3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyridine::CHEMBL559456::rac-3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyridine

SMILES Clc1cccc(OC(C2CCNCC2)c2cccnc2)c1Cl

InChI Key InChIKey=NTBRVAZZXJHBGJ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50294270   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  150nMAssay Description:Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  71nMAssay Description:Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294270(3-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)pyr...)
Affinity DataIC50:  150nMAssay Description:Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed