BDBM50294687 3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)benzyl)propanamide::CHEMBL562971

SMILES CNc1nc2[nH]c(cc2c2n(C)cnc12)-c1cccc(CNC(=O)CCOC)c1

InChI Key InChIKey=HLIYWFVKEYJMNH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50294687   

TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50294687(3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50:  12nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50294687(3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50294687(3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human IKK2-mediated GST-IkappaBalpha protein fusion phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50294687(3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50:  2.62E+3nMAssay Description:Inhibition of IKK2-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed