BDBM50295553 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol::4-[4-(4-Fluoro-phenyl)-1-(3-phenyl-propyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-but-3-yn-1-ol::CHEMBL190333::RWJ-67657::US11273153, Compound RWJ67657

SMILES OCCC#Cc1nc(c(-c2ccncc2)n1CCCc1ccccc1)-c1ccc(F)cc1

InChI Key InChIKey=QSUSKMBNZQHHPA-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50295553   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataKi:  13nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataKi:  13nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataKi:  13nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataKi:  210nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataKi:  210nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataKi:  210nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase(Toxoplasma gondii)
Tulane University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Toxoplasma gondii recombinant MAPK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant p38alpha assessed as [gamma33P]ATP utilization by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Everbrilliant Pharma

US Patent
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataIC50:  30nMAssay Description:FP signals were measured with a PHERAstar microplate reader (BMG Labtech) using black, low-binding half-area 96 well plates (Corning). Each binding d...More data for this Ligand-Target Pair
In DepthDetails US Patent