BDBM50296851 2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid::CHEMBL561539

SMILES Cc1c(CC(O)=O)c2cccnc2n1S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=SFUKQIBDQAEIQC-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50296851   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataKi:  103nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataKi:  103nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human thromboxane A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataIC50:  108nMAssay Description:Antagonist activity at CRTh2 receptor in human isolated eosinophil assessed as inhibition of DK-PGD2-induced shape change after 5 mins by flow cytome...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataIC50:  108nMAssay Description:Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataIC50:  565nMAssay Description:Antagonist activity at human CRTh2 receptor expressed in CHO cells assessed as inhibition of prostaglandin D2 and forskolin-induced cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed