BDBM50297145 (R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahydro-10-thia-5,8-diaza-benzo[a]azulen-9-one::CHEMBL559411

SMILES COCCOc1ccc2sc3c(NC[C@@H](C)NC3=O)c2c1

InChI Key InChIKey=KCXYHUJEGPMBKM-SECBINFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297145   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  270nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  81nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed